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Five-year study shows CBD oil helps treat diabetes
With CBD use on the rise, many doctors are questioning whether they should prescribe the plant compound for diabetes to help patients cope with the symptoms and even fight the disease itself.
Dr. Allan Frankel, an M.D. with Greenbridge Medical, wrote onOCCNewspaper recently about the experiences and successes he’s had treating his diabetes patients with CBD oil, concluding that it can help with both the treatment of the disease itself, as well as aiding the day to day management of diabetes related symptoms like inflammation and joint pain.
“For certain, it is worth a try.”
CBD Oil For Diabetes: What Do Patients Say?
We spoke to Pete Jarlett, a diabetes patient to get a personal view on how CBD oil for diabetes can be beneficial. He has been treating his diabetes with a combination of a Ketogenic diet (healthy fats) and CBD oil, on the advice of Dr. Joseph McCall and HoneyColony cofounder Maryam Henein.
“Overall, I feel a million times better, but everyone has to make their own decision. I feel strong and I’m getting my energy back.”
Jarlett even enjoys cooking with CBD oil although temperature is important to consider to not destroy the healing properties.
“You can even elevate the CBD oil at the pinnacle with other oils. Once you can work it into your diet it can be so easy.”
Diabetes: Relentless Rise
Diabetes refers to the group of metabolic disorders characterized by high blood glucose levels; almost 400 million people worldwide suffer from either type one or type two diabetes and it kills up to 5 million people every year. Type one diabetes is caused by an autoimmune attack on the islet cells in the pancreas (which produce insulin), while type two diabetes develops as a result of defective insulin production and insulin resistance.
Diabetes rates are on the rise, due in part to the high levels of sugar consumptionin today’s society, although other factors can contribute, such as Epstein Barr virus and toxins in our food and air supply. Because of the heightened burden on the medical infrastructure, there has been a bigger push towards innovative techniques to treat the disease, rather than simply managing it with insulin shots. CBD oil might be one such treatment. Since 2005 there has been an explosion in research surrounding diabetes and the use of CBD as a form of treatment; Project CBD is dedicated to compiling data and research relating to the effects of CBD on diabetes sufferers.
The 2005 research paper from the American Alliance for Medical Cannabis (AAMC) lists numerous benefits that both CBD and cannabis can have for diabetes sufferers including:
- Stabilizing blood sugars
- Arterial anti-inflammatory properties
- “Neuroprotective” effects that help prevent inflammation of nerves and reduce the pain of neuropathy
- “Anti-spasmodic agents” help relieve muscle cramps and the pain of gastrointestinal (GI) disorders
- Acting as a “vasodilator” to help keep blood vessels open and improve circulation
- Lowering blood pressure — which is vital for diabetics
- Helping calm diabetic “restless leg syndrome” (RLS
Diabetes is the name used to refer to a cluster of metabolic disorders characterized by the prolonged presence of high glucose levels in the blood. There are about 400 million of people that are affected by diabetes worldwide, and year after year, its prevalence continues to rise. Various treatments for diabetes are available. Recently, significant evidence was found suggesting positive effects of (Cannabidiol) CBD for diabetes.
What is Diabetes?
Diabetes or diabetes mellitus is a group of diseases targeting the metabolic processes and characterized by the high blood glucose levels. The two most common forms of diabetes is the Type 1 and Type 2 diabetes. In both Type 1 and Type 2 diabetes, the elevated blood glucose levels soon lead to metabolic and non-metabolic complications.
- Type 1 Diabetes
This type of diabetes is often diagnosed in individuals aged below 30. It often involves an autoimmune attack on the pancreas’s islet cells. These are the cells in the body that produces insulin. There are about 10% of diabetics suffering from Type 1 diabetes worldwide.
- Type 2 Diabetes
The Type 2 diabetes is more common compared to Type 1 diabetes. This type of diabetes mostly affects individuals who aged over 40 and those who are obese. Type 2 diabetes is mostly the result of insulin resistance combined with defective insulin production.
CBD for Diabetes: Treatment for Disease and Symptoms
In the recent years, numerous cannabis researches are being conducted so as to find its said health benefits. In all these researches conducted, it has been said that cannabis has many significant effects in various diseases including diabetes. There are millions of people that are affected by diabetes across the world.
With researches and studies conducted saying that cannabis has significant positive effect in treatment and control of the disease, it is truly an interesting subject. Well then, what are these said positive effects of CBD for diabetes? How does Cannabidiol help patients suffering from the different symptoms of diabetes?
Studies in mice have shown that the incidence of diabetes in non-CBD-treated mice was significantly reduced from 83% to 30% when treated with CBD. Treatment with CBD also shows a significant reduction in plasma levels of proinflammatory cytokines (IFN-gamma and TNF-alpha.)
The production of Th1-associated cytokine from in vitro activated T cells and peritoneal macrophages was also significantly reduced in the mice treated with CBD. While the production of IL-4 and IL-10 (Th2-associated cytokines) was increased compared to mice not treated with CBD.
The histological examination of CBD-treated mice on the pancreas showed significantly reduced insulitis. Source : https://www.ncbi.nlm.nih.gov/pubmed/16698671
Diabetes is connected with high levels of the fasting insulin, insulin resistance and low levels of high-density lipoprotein cholesterol (HDL-C). In the past year, a study on cannabis’s effects on fasting insulin and insulin resistance shows that cannabis users have lower fasting insulin levels.
This is compared to those that have never used cannabis before. In addition, those who have used cannabis long before but is not current users have similar but less pronounced low level fasting insulin. This indicates that the cannabis’ protective effect fades after some time.
Excluding diabetics, researches still found that current cannabis users have reduced levels of insulin resistance and fasting insulin. This shows that not only cannabis helps in controlling the symptoms of diagnosed diabetics but also in preventing its occurrence in the first place.
Insulin is a hormone produced by pancreas and is essential in regulating glucose metabolism.
Insulin resistance is linked with Type 2 diabetes where the insulin production is not affected, the cells cannot process it.
With the cells becoming resistant to insulin, they become unable to absorb glucose which is needed in supplying the body with energy. When the unused glucose in the bloodstream builds up, this eventually leads to development of hyperglycemia. In the recent studies on CBD for diabetes, it has been found that cannabis users have blood glucose in significantly low levels compared to cannabidiol non users.
The nerve damage induced by diabetes often affects the extremities such as hands and feet.
But they may also affect any organ or in any region of the body.
Diabetes’s nerve damage can be symptomless but in most cases, there is pain, numbness and tingling that accompanies it.
Treating diabetic neuropathy with conventional analgesics can be difficult. However, evidences were found that cannabis might also help in the treatment of diabetes-induced nerve damage. Cannabidiol extracts comes with pain-reducing effects and this was shown to have pronounced effect in neuropathy induced by diabetes.
In the study conducted related to CBD for diabetes and neuropathy, it seems like repeated administration has positive effect on mechanical allodynia and was also found to restore normal pain perception. CBD was found to have positive effects on nerve pain, protecting the liver from oxidative stress and restoring nerve growth factor back to normal levels.
Weight gain and obesity are both connected to diabetes risks. As obesity is associated with diabetes, many studies on cannabis’s effects on weight gain has been conducted. But these studies all have conflicting results that has made it difficult to establish how cannabis can help with diabetes in relation to weight gain.
However, a recent study shows that after being exposed to organic cannabis extract, obese rats lost weight significantly as well as gained an increase in pancreas’ weight. This shows that the presence of cannabinoids protect the beta cells of pancreas. This may help in controlling the disease as an autoimmune response destroys beta cells in type 1 diabetes.
Majority of diabetics acquire diabetic retinopathy after a long time of struggling with the disease. Diabetic retinopathy (DRP) is a complication wherein the cells of the retina become progressively damaged over time. The complication is related with breakdown of the blood-retinal barrier in the eyes preventing substances in the blood to enter the retinal tissue.
The breakdown of the retinal barrier is induced by glucose and is the cause for the neural tissue becoming exposed to neurotoxins. In addition, the blood-retinal barrier’s breakdown increases the chance of retinal bleeding. There is evidence found that cannabidiol can help in diabetes retinopathy as it is capable of combating inflammation and oxidative stress.
Both of these play a role in retinal cells’ breakdown. In the studies conducted in the relationship of diabetic retinopathy and cannabis, the results were quite positive in showing that cannabis is capable of significantly reducing neurotoxicity as well as oxidative stress. With that, the death of retinal cells as well as blood-retinal barrier’s breakdown can very well be prevented.